The Journal of Minimally Invasive Gynecology
Volume 17, Issue 4 , Pages 449-455, July 2010

Clinical Use of Misoprostol in Nonpregnant Women: Review Article

  • Chainarong Choksuchat, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: Chainarong Choksuchat, MD, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkhla University, Hat-Yai, Songkhla 90110, Thailand.

Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, Thailand

Received 30 December 2009; accepted 12 March 2010.

Abstract 

Misoprostol, a prostaglandin E1 derivative, has been widely used in nonpregnant women because of its cervical ripening and uterotonic effects. A large number of studies have demonstrated its effectiveness in enhancing ease of cervical dilation. This review article describes its pharmacokinetic profile and the relationship between prostaglandins and cervical ripening and uterine contraction and provides a review of the clinical use of misoprostol in nonpregnant women including cervical priming before hysteroscopy, before insertion of an intrauterine device, in endometrium biopsy, preoperatively in myomectomy, and before intrauterine insemination to improve pregnancy rates. Adverse effects are also described.

Keywords: Biopsy, Endometrium, Gynecology, Hysteroscopy, Intrauterine device, Intrauterine insemination, IUD, IUI, Misoprostol, Myomectomy

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 The author has no commercial, proprietary, or financial interest in the products or companies described in this article.

PII: S1553-4650(10)00128-7

doi:10.1016/j.jmig.2010.03.015

The Journal of Minimally Invasive Gynecology
Volume 17, Issue 4 , Pages 449-455, July 2010

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